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During the first three sessions, participants were exposed to three different, blinded doses of intranasally administered nicotine (0, 0.5, 1.0 mg) across three separate fixed dose experimental sessions

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Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation, airway remodeling and/or destruction of the alveoli (emphysema), leading to airflow limitation [1]