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They improve lipid profile, enhance insulin sensitivity, reduce inflammation, and promote metabolic homeostasis ( Nutritionally, the PPARs evolved as a fatty acid-activated nuclear receptors, where long chain fatty acids are the key molecular targets, to effect regulation of signal transduction processes and gene regulation, which in turn dictate their roles in health and disease ( In the literature, a number of chemicals have been implicated in relation to obesity, including bisphenols, pesticides, phthalates, metals, and perfluorinated compounds

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The cells were transferred to 6-wells plates with 3 mL of pre-warmed complete medium