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This primer will set the stage for part two of this article which will tackle two important issues: 1) Should athletes supplement with antioxidants to protect against exercise-induced oxidative stress

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Figure 1 2.1 The core enzymatic triad: BCAT4, MAM1, and CYP79F1 The commitment of methionine to aliphatic glucosinolate synthesis is driven by three pivotal enzymes, each executing a distinct and non-redundant step in the construction of the glucoraphanin backbone ( Figure 2 )

Observational studies have tracked the effects of caloric restriction on lean, healthy individuals, and demonstrated that moderate restriction (2230% decreases in caloric intake from normal levels) improves heart function and reduces markers of inflammation (C-reactive protein, tumor necrosis factor [TNF]), risk factors for cardiovascular disease (LDL cholesterol, triglycerides, blood pressure), and diabetes risk factors (fasting blood glucose, insulin levels)