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Retatrutide redesigns multi-agonism Approval Outlook Neither CagriSema nor Retatrutide should be treated as FDA-approved therapy in 2026 until regulators say otherwise

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In pancreatic beta cells, GLP-1 receptor engagement boosts glucose catabolism and insulin secretion through the mTOR-dependent HIF-1 pathway, facilitating glycolysis and more robust insulin release

Therefore, potential sex-related differences in the effectiveness or tolerability of dose escalation could not be assessed, and the applicability of these findings across women and men should be interpreted with caution