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However, this can be a double-edged sword, as in many cases increasing the volume of food achieves satiety before the end of the meal, thus jeopardising the intake of macronutrients, especially protein, which is associated with improved body composition

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There have been postmarketing reports of renal impairment, acute kidney injury, and worsening of chronic renal failure, which sometimes has required hemodialysis, in patients treated with GLP-1 receptor agonists