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The same principle applies to peptide injections

Due to the negative effects of thiazolidinediones on bones (29) and fluid retention which would add to the ones of hypercortisolism metformin either as monotherapy or, if glycemic targets cannot be reached, in combination with other oral antidiabetic drugs, GLP-1 receptor agonists or insulin should be considered as first choice

Reduced free carnitine and increased serum and urine acylcarnitine levels were also demonstrated in patients with VPA-induced Reye-like syndrome [45]

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