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Abdominal obesity In a 12-month clinical trial published in 2010, which involved 404 HIV-infected patients with excess abdominal fat, the group that received 2mg of tesamorelin per day saw an 18% decrease in visceral fat compared to placebo.9 There are two things to note in order to appreciate the full scope of these findings: Visceral fat (i.e., fat accumulation around the abdominal organs) is famously stubborn and cant be burned selectively through exercise

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Numerous studies underscore their capacity to downregulate lipogenic transcription factors (such as SREBP-1c and ChREBP), activate lipid oxidation pathways via AMPK and PPAR, enhance mitochondrial function, and reinforce antioxidant defenses through upregulation of Nrf2-mediated gene expression

The most significant weight loss results are typically observed after several months of consistent use