fda compounding semaglutide crackdown october 2025 New project announcement: HHS‑OIG is taking a closer look at FDA's oversight of compounded GLP‑1 drugs. Although shortages ended in 2025, some facilities may still be producing these drugs at scale. Our Compounded Semaglutide: Legal & Safe

On immune cells, inhibition of DPP-4/CD26 results in anti-inflammatory effects via regulation of chemokines and anti-inflammatory cytokines like IL-10 and transforming growth factor (TGF)- (83, 84) and DPP-4 might also impact macrophage polarization

doi: 10.1038/srep05640 148 Segura-MorenoYYSanabria-SalasMCMesaJAM-LDVarela-RamirezRAcosta-VegaNLSerranoML

PlexusDx sources compounded semaglutide from licensed 503A compounding pharmacies, which operate under strict FDA oversight and quality standards

[4] observed a lower sucrose and sodium chloride threshold in obese compared to lean participants and concluded that obese individuals show a higher sensitivity for sweet and salty taste