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4), the hallmark lesions of chronic TB, are well-organized, compact structure composed of differentiated macrophages, lymphocytes, and other immune cells [96, 97]

Western blot assay K7M2 cells were incubated with the PBS, Ru(II)-OH, NP2, or NP4 (10 M Ru) for 12 h at 37 C, and the supernatant was subsequently co-incubated with RAW264.7 cells

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This timeline was chosen based on previous studies indicating the peak of inflammatory and oxidative stress responses post-sepsis induction within this timeframe 27