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Bioavailability is the most critical factor in supplement effectiveness

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Gather your support You already know diet and exercise are crucial for weight-management success on GLP-1s, but social support is just as important, says clinical psychologist Sherry Pagoto, PhD, professor in the Department of Allied Health Sciences at the University of Connecticut and director of the UConn Center for mHealth and Social Media

Medical Conditions and Medication Interactions Certain medical conditionsincluding thyroid disorders, polycystic ovary syndrome (PCOS), hormonal imbalances, and severe insulin resistancereduce semaglutide's effectiveness or complicate weight loss even at optimal doses