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Early clinical trials of glutamine antagonist metabolites have revealed unacceptable systemic toxicity, highlighting the need for more selective approaches to disrupt glutamine metabolism in cancer patients [225]

Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines

In addition, as you get older your bodys ability to absorb B-12 through digestion continually decreases

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