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NICE guidance (NG28) on type 2 diabetes management supports stepwise treatment escalation, with GLP-1-based therapies like Mounjaro typically reserved for patients who have not achieved adequate control with other agents

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It's crucial to discuss any previous medical history with your provider to ensure an appropriate and safe treatment path

As the hepatic T4 to T3 conversion is stimulated in response to feeding 16 , the role of hepatic TH signaling in the metabolic response to nutrient ingestion has been of interest