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Over time, this repeated irritation can cause the gums to recede, exposing the root of the tooth and increasing sensitivity. The expert encourages users to look out for early warning signs such as tenderness, persistent soreness, ulcer-like patches and visible gum recession in the area where the pouch is placed. Dr Suzanne Wylie, GP and medical adviser for IQdoctor, also has her concerns, sharing with Metro : Regular use can lead to dependence, increased heart rate and blood pressure, headaches, nausea, mouth irritation and gum problems. That said, when discussing them in the context of a cigarette alternative, she notes: If someone is a long-term smoker and has completely switched from cigarettes to nicotine pouches, then it is very likely they have reduced their exposure to many of the most dangerous toxins associated with tobacco smoke, and from a harm-reduction perspective that is probably a positive step
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There were no meta-analyses, pooled studies, or indeed individual interventional studies, which perhaps reflects difficulty conducting these in real world settings
