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The profiles were relatively flat, supporting low variability over time as well as low variability between subjects

Hunger between meals becomes more pronounced

Severe or persistent gastrointestinal symptoms may result in fluid and electrolyte depletion, potentially causing: Tachycardia (increased heart rate) as a compensatory response to volume depletion Orthostatic hypotension (dizziness upon standing) due to reduced blood volume Palpitations or irregular heartbeat sensations Fatigue and weakness that may be mistaken for cardiac symptoms Patients should maintain adequate hydration and seek medical attention if experiencing persistent vomiting or diarrhea lasting more than 24 hours

in human adipocytes, tirzepatide stimulates lipolysis, releasing glycerol into circulation for energy needs [78]