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Previous reports also suggest downregulation of ERK in GNE deficient cells 8,15,48

This is tremendously interesting, but not super relevant to understanding the article

This task could deplete the bodys glutathione reserves

In mammals, biotin is a coenzyme of four major carboxylases (pyruvate carboxylase, propionyl coenzyme A carboxylase, 3-methylcrotonyl coenzyme A carboxylase, and acetyl coenzyme A carboxylase)