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In parallel, combined exposure also results in global DNA hypomethylation, a hallmark of many cancers ( Together, these epigenetic alterations, including site-specific methylation changes and global DNA hypomethylation, destabilize the genome, silence tumor suppressor genes, and enhance the metabolic activation of carcinogens

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It distributes brands like Du Maurier, John Player, Matine, Pall Mall, Viceroy, Vogue, and licenses Marlboro from Philip Morris