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Redheuil, A

doi:10.1177/193229681000400218 Cirillo F, Catellani C, Lazzeroni P, et al

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This complexity challenges static treatment paradigms and limits the effectiveness of sequential monotherapy approaches in heterogeneous disease settings., The tumor microenvironment is not merely a passive scaffold for resistance, but an active and dynamic contributor that shapes both tumor evolution and treatment response and disease persistence