dpp 4 and glp 1 together DPP4 Inhibitors vs GLP-1 Agonists | June 2021 | Clinical Corner The mechanism of action of

Tachyphylaxis where drugs become less effective over timecreates another key difference

Data accumulated from animal experiments conducted in acute ischemic stroke models with and without diabetes have also demonstrated a dose-dependent reduction of infarct volume in the brain by GLP-1RAs, when administered before or during the acute phase of ischemia at reperfusion or with some delay after the onset of reperfusion [60,61,62, 70]

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J Neurosci 28:1357413581 Waak J, Dringen R (2006) Formation and rapid export of the monochlorobimaneglutathione conjugate in cultured rat astrocytes