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Alicic RZ, Neumiller JJ, Tuttle KR

Both show dose-dependent GI side effects managed through escalation protocols

Some studies have identified a correlation between T2DM and oxidative damage or antioxidant status [307,308,309]

As the loss of POLRMT results in severe mitochondrial dysfunction in cardiac muscle 70 , a similar mitochondrial dysfunction should occur in beta-cells with the loss or dysfunction of POLRMT, resulting in insulin resistance and diabetes mellitus