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Start your intake How Gila Monster Venom Led to GLP-1 Discovery Scientists studying Gila monster venom discovered a peptide called exendin-4 that mimicked a natural human hormone called glucagon-like peptide-1 (GLP-1)

These and other, similar pharmaceutical interventions soon began to be applied and even prescribed solely for weight reduction

These belong to a class of drugs called incretin mimetics , which either mimic or enhance the effects of gut hormones that regulate appetite and metabolism

If a statin-based regimen is not tolerated at any dose, ezetimibe can be combined with a PCSK9 inhibitor or used alone