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As an important regulator of Wnt transduction in the canonical signaling pathway in tumours, Dickkopf-related protein 3 (DKK3) negatively regulates aerobic glycolysis [HK2, HIF-1, GLUT-1, LDHA and 3-phosphoinositide-dependent protein kinase-1 (PDK-1)] in BxPC-3 cells

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Whether allosteric receptor modulators could be exploited for therapeutic gain awaits further study [81, 87]