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V., Borelli, A

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Thirty-six percent had confirmed DPN, and 33% exhibited abnormal thermal sensation

Subsequently, steroid glycoside H.g.-12, extracted from the plant Hoodia gordonii [which tastes bitter, and has potent appetite-suppressant effects in both animals and humans (64)] was found to induce CCK secretion both ex vivo from rat intestine, and from HuTu-80 cells ( ad libitum meal in healthy young individuals (62)