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We observed that WY14643 treatment resulted in greater protein expression of the complex I subunit NDUFA9 compared to controls, however, changes in other OXPHOS subunits were not found (Fig

Supplementary Material Ethical Statements Not applicable

This stratified approach avoids the one-size-fits-all assumptions that have constrained past indication extension attempts and provides a clearer, evidence-led path to expanding GLP-1 use where it is biologically and clinically justified.

Cardiovascular Emerging Evidence Evidence Rating: Emerging (Preliminary animal data) Cardiovascular applications are less studied but intriguing: Cardiac protection Arrhythmia prevention Blood vessel healing Collateral vessel formation Regulatory Status FDA Classification BPC-157 is not approved by the FDA for any medical use in humans