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Monitor Changes in Limb Measurements Significant weight loss can alter: Limb circumference Tissue texture Garment fit Compression requirements Regular reassessment is critical

Several metabolic adaptations make it challenging to sustain weight loss long-term, including hormonal changes, increased food noise, and the energy gap. Shifts in Hunger Hormones Hunger and satiety are partially driven by hormones released from the gut to the hypothalamus (a region of the forebrain)

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Therapy is usually combined with periodic monitoring to evaluate body composition, metabolic markers, and subjective symptom changes