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(You might remember when compounded GLP-1's gained popularity a few years ago during the shortage of FDA-approved options like Ozempic.) Compounded drugs aren't FDA approved, which means the FDA hasn't reviewed their safety, quality or effectiveness

Additionally, zinc acts as a cofactor for superoxide dismutase (Cu/Zn SOD) and regulates the expression of metallothioneins, which scavenge ROS (367)

Some groups of people appear to be more vulnerable than others, and for them, the possible downsides can outweigh any hoped-for benefits