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Indeed, in the UK, injectable GLP-1 receptor agonists are only recommended as an intensification step for patients with inadequate glycaemic control following a triple therapy combination of metformin plus a DPP-4 inhibitor with a sulfonylurea, pioglitazone or an SGLT2 inhibitor, for whom insulin therapy would have significant occupational implications or weight loss would benefit other obesity-related comorbidities [6]

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Again, using the 10mg dose as it has the cleanest signal, about a 20% drop in LDL and a 32% drop in triglycerides