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VIP exerts its effects by binding to specific G-protein coupled receptors, notably VPAC1 and VPAC2 receptors, which are present in various tissues including the brain, gastrointestinal tract, and immune system [3]

B12 deficiency can affect individuals of all ages, but most particularly elderly individuals, as older adults are more likely to have decreased stomach acid production, which is necessary for B12 absorption and they easily develop vitamin B12 deficiency

Our pilot studies suggest opiorphin promotes sperm motility and may positively influence sperm motility parameters in some cases of males infertility characterized by asthenozoospermia

PMC 4309162