Laube et al., 2002
Using TRRUST ( Figure 3C and Supplementary Table 5A )
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Patients who I recommend be screened for MTHFR mutations: Mood disorders: depression, anxiety, irritability, mood swings, bipolar Infants and children of parents with MTHFR mutations Family members related to someone with MTHFR mutations Infertility and Pre-conception care: test both man and woman Elevated folate (not processing to active 5-MTHF due to inability to methylate) Elevated homocysteine (due to low active 5-MTHF and methylcobalamin) Elevated s-adenosylhomocysteine (due to low active 5-MTHF and methylcobalamin) Elevated serum cobalamin (due to inability to methylate cyanocobalamin to methylcobalamin) Elevated methylmalonic acid (due to methylcobalamin deficiency) Patients with syndromes: IBS, multiple chemical sensitivity, fibromyalgia, Down syndrome, chronic fatigue syndrome Neurological disorders: Multiple sclerosis, Autism, Alzheimers, Epilepsy, Parkinson's Cancer: family history of cancer or undergoing cancer treatment Cervical dysplasia Cardiovascular risk: family history of strokes, embolisms, heart attacks, clots, hypertension Birth defects: cleft palate, tetralogy of Fallot, spinal bifida, midline defects Drug sensitivities: methotrexate, anti-seizure meds, nitrous oxide, anesthesia If you are interested in knowing more about your genes, the 23andme gene test will be the best $99 investment you've ever spent
