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Neuropeptides can act directly through their receptors and regulate airway smooth muscle tone, bronchial blood flow and airway secretion or act on inflammatory cells, contributing in this way to inflammatory process and ventilation in asthma pathology (Figure 1) [5,7,8,9]

This usually includes evidence of a BMI above 27 with comorbidities (hypertension, diabetes, sleep apnea) or BMI above 30, plus documentation of failed prior weight loss interventions

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Oral forms exist but are less effective, particularly for gastrointestinal issues, as injected forms seem to yield better clinical responses 6