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Its not clear to me if this was the FDAs decision or if Lilly didnt file the 36mg due to GI side effects and possibly liver enzyme concerns (I guess Lillys choice) Sorry, but going from 225 to 200 (not a pun) isn't really moving the needle enough

However, because of potential side effects like skin rashes or the reversion effect where results fade after stopping treatment, you must not attempt to self-medicate

Available pen strengths deliver weekly doses typically titrated from 0.25 mg to 0.5 mg, with maintenance doses of 1 mg or 2 mg based on response and tolerability

EVOKE Plus allowed the participation of patients with significant small vessel involvement, while EVOKE did not