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Why it's included Included for its supportive role in metabolic function and its potential to help ease nausea, which can occur with GLP-1 therapies

Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)

Conditions like G6PD deficiency, chronic kidney disease, or autoimmune syndromes can also change the risk profile