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E 9.9 Among patients with type 2 diabetes who have established atherosclerotic CVD (ASCVD) or indicators of high risk, established kidney disease, or HF, a sodiumglucose cotransporter 2 (SGLT2) inhibitor or glucagon-like peptide 1 (GLP-1) receptor agonist with demonstrated CVD benefit (Table 9.1) is recommended as part of the glucose-lowering regimen independent of A1C and in consideration of patient-specific factors

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Semaglutide Examined in Older Adults Older adults with obesity are often considered medically vulnerable because they frequently have multiple health conditions and greater frailty, which can increase the risk of adverse events (AEs)

Together, these results suggested a potential role of GLP-1R in OA