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Gastrointestinal adverse events were dose-related, mostly mild, and transient

The exact minimum effective concentration that recapitulates our observed suppressive ILC2 phenotype in vivo , remains to be determined, and will likely rely on a complex grouping of factors that take into account systems with endogenous melatonin rhythms (such that were absent in our studies both in vitro and in vivo with BALBc mice)