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However, this anti-inflammatory effect did not translate into improved clinical outcomes, as clinical scores increased and antimicrobial usage rose following cessation of MT 175 , suggesting that the gutlung axis involves complex mechanisms that require further optimization

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doi: 10.1016/J.JACI.2014.04.015 187 ZuidmeerLGoldhahnKRonaRJGislasonDMadsenCSummersCet al

NASH caused hepatomegaly, fibrosis, and inflammation in all mice, with aged mice showing increased heart weight, left ventricular volumes, and subtle systolic and diastolic dysfunction, thus NASH tends to worsen age-related cardiac dysfunction [37]