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Mice that underwent GCLC ablation were found to have lower levels of GSH and a severely impaired Th17 immune response to GI infections demonstrating decreased survivability compared to non-ablated counterparts [65]

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FOXO4-DRI is among the highest-risk research peptides from an evidence-to-risk standpoint: it has never been tested in humans, no human pharmacokinetic data exists, and as a senolytic it carries theoretical risks specific to its mechanism