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Underlying the complex interplay between depression and neuroinflammation is a bidirectional relationship in which depression can induce a neuroinflammatory state, leading to impairments in brain function that can further exacerbate mood disorders

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These symptoms are associated with the progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta (SNpc) and the presence of lewy bodies, composed of -syn aggregates [114, 115]