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Vitamin C does not seem to cause significant adverse or toxic effects, and as such there is no upper limit, but very high doses, over 1000mg have been linked to gastrointestinal discomfort, including nausea, cramps and diarrhoea

The brain perceives this sudden drop as a life-threatening emergency and responds by dumping massive amounts of catecholamines (like adrenaline and norepinephrine) into the bloodstream to force the liver to release stored glucose

[30] The conjugation process is illustrated by the metabolism of N -acetyl- p -benzoquinone imine (NAPQI)

Overdoing fiber supplements or neglecting hydration can worsen constipation, diarrhea, or dehydration