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Given the central role of GPX4 in inhibiting lipid peroxidation, preventing ferroptosis, and maintaining the structural integrity of cellular and mitochondrial membranes ( and nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathways, as well as its downstream biological effects, such as impacts on chondrocyte survival, inflammatory responses, and ECM metabolism

Over 12 months, 87.8% of participants taking tirzepatide lost 5% or more of their starting weight vs

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