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The excess production of NADH during the catabolism of proline in the gdh3 / gdh3 mutant could be at the expense of NAD + supply and formation of the NADPH needed for cellular division and hyphal development

van der Kloet, F

In addition, the transition from laboratory-scale research to clinical application faces substantial barriers, including extensive preclinical testing to establish safety and efficacy, the complexities of large-scale manufacturing to ensure consistent quality, and the rigorous regulatory approval processes that demand considerable time and resources (Oliva et al., 2021

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