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doi: 10.1016/j.jhep.2022.06.012 193 SubramanianPHampeJTackeFChavakisT

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The largest meta-analysis to date, comprising 13 cardiovascular outcome trials involving 83,258 patients with and without diabetes, confirmed that GLP-1 Ras significantly reduced major adverse cardiovascular events (MACEs), all-cause mortality, cardiovascular mortality, fatal and non-fatal strokes, coronary revascularization, and composite kidney outcomes [87]

5 The gut-liver-kidney axis: a pathological network of nutritional metabolic disorders in diabetic kidney disease 5.1 Molecular basis of inter-organ metabolic crosstalk 5.1.1 Systemic circulation of gut-derived metabolites Research on the pathogenesis of diabetic kidney disease (DKD) has shifted from a single-organ perspective to an integrated view of multi-organ network regulation