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Unlike other forms of regulated cell death, cuproptosis is characterized by the direct binding of reduced copper (Cu + ) to lipoylated proteins of the tricarboxylic acid (TCA) cycle, most notably dihydrolipoamide S-acetyltransferase (DLAT), together with destabilization of iron-sulfur (Fe-S) cluster proteins such as succinate dehydrogenase complex ironsulfur subunit B (SDHB) 164

People with obesity tend to have a poorer response to some disease-modifying therapies, particularly older first-line treatments, compared with people at a healthier weight, she says

The dose is typically increased after a few weeks based on tolerance and treatment response, under medical supervision