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Glycine, though technically classified as a non-essential amino acid, becomes conditionally essential when the body is under high oxidative demand, as the endogenous synthesis cannot keep up with the rapid consumption

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Common side effects include: Gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) Decreased appetite and potential malnutrition in vulnerable individuals Risk of hypoglycemia when combined with insulin or sulfonylureas Rare but serious risks including pancreatitis and gallbladder disease Important safety considerations include: Boxed warning for thyroid C-cell tumors in rodents

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