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Moreover, Cl-2TG mice demonstrated marked suppression of the colitis-induced immune activation and associated signaling, suggesting development of immune adaptation

demonstrated that postbiotics derived from Lactobacillus plantarum significantly reduced serum transaminase and triglyceride levels in mice with acute alcohol-induced liver injury by protecting hepatocytes from oxidative damage, improving lipid metabolism, and modulating the intestinal microbiota [225]

Other medical conditions and comorbidities Autoimmune diseases , diabetes , thyroid disorders , and chronic inflammatory states increase nerve sensitivity and reduce treatment response