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As such, the expression of all the renin-angiotensin-aldosterone system (RAAS) componetns have been shown in several tissues, including brain, heart, vasculature and kidney

Conflicts of Interest The authors declare that they have no conflict of interest

Because it ensures consumer safety and protects against potentially harmful practices

Both disproportionality analyses confirmed this heightened risk: ROR analysis showed a statistically significant association (ROR = 1.81, 95% CI 1.622.03), while BCPNN yielded an information component of IC = 0.85 (IC025 = 0.69), both indicating substantially greater renal impairment risks in this older population treated with the combination therapy