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Abbreviations OA: Osteoarthritis DAMPs: Damage-associated molecular patterns PRRs: Pattern recognition receptors TLRs: Toll-like receptors IL-1: Interleukin-1beta TNF-: Tumor necrosis factor alpha IL-6: Interleukin-6 ROS: Reactive oxygen species MMPs: Matrix metalloproteinases GSDMD: Gasdermin D GWAS: Genome-Wide Association Studies SNVs: Single nucleotide variants KOA: Knee osteoarthritis GRS: Genetic risk scores PRS: Polygenic risk score ECM: Extracellular matrix lncRNAs: Long non-coding RNAs miRNAs: MicroRNAs GC-TOF/MS: Gas chromatography - time-of-flight/mass spectrometry scRNA-seq: Single-cell RNA sequencing PTOA: Post-traumatic osteoarthritis CSPCs: Cartilage stem/progenitor cells RA: Rheumatoid arthritis MRI: Magnetic resonance imaging IPFP: Infrapatellar fat pad iROA: Incident radiographic knee OA References Hunter DJ, Bierma-Zeinstra S

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