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While tirzepatide is not designed to target sexual function directly, its mechanisms can influence libido indirectly through several pathways: Appetite regulation and reduced caloric intake Improved insulin sensitivity and glucose control Weight reduction and metabolic efficiency Changes in energy balance and fatigue GLP-1 and GIP receptors are also present in the brain, meaning tirzepatide may subtly affect central nervous system signaling related to motivation, reward, and mood all of which can influence sexual desire
Severe adverse events were assessed by BMI category
Hence, there is a further need for comprehensive large-scale collaborative analysis about neurotransmitter homeostasis and their energetics to better understand the etiology of depression similar to that proposed by the ENIGMA consortium for genetic and neuroimaging data
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