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The copper coordination in GHK-Cu reduces (but does not eliminate) free copper availability compared to copper salts, but the catalytic degradation of vitamin C is still a real formulation concern at low pH levels where ascorbic acid is most active

In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]

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