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Together, they address both vascular supply and cellular repair simultaneously, potentially accelerating overall tissue regeneration timelines beyond what either peptide achieves alone in preclinical models

Excellent sources include wholegrain cereals, brown rice, wholemeal bread, fruits (particularly prunes, pears, and apples with skin), vegetables, pulses, and nuts

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Moreover, the TGF1/Smad3 signalling pathway reduces the loss of ECM by inducing the production of TIMP-2 and inhibiting the activity of MMP2/9 (Liu et al