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(For further information about smoking cessation in this population, refer to Chapter 4: People with mental illness)

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Funding: Funding for this work came from two awards granted to REM: award 26IR-0003 from the Tobacco Related Disease Research Program ( and 19-10107 from the California Tobacco Control Program ( The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Histology and immunofluorescence Organoids were washed to remove basement membrane extract, fixed in 4% paraformaldehyde, embedded in Histogel, paraffin-processed, sectioned (4 m) and stained according to standard hematoxylin and eosin (H&E) protocols