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We also focused on the nine toxicants (acetaldehyde, acrolein, benzo[a]pyrene, benzene, 1,3-butadiene, carbon monoxide (CO), formaldehyde, nitrosonornicotine (NNN) and 4-( N -nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) recommended for mandated reduction in cigarette smoke by the WHO Tobacco Product Regulation Group (WHO TobReg) which are also part of the HPHCs U.S.FDA list 53,54,55

However, some countries with stricter vaping laws like Thailand, where vapes are banned may require declaration or confiscate devices

Therefore, the FDA is recommended to continue to evaluate the impact of flavorings and product design on e-cigarette product appeal through PMTAs and post-market surveillance to ensure that product authorization for market entry does not instigate use among young people

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